Publications

The Simplified MPP Isolation Scheme: establishing a consensus approach for multipotent progenitor identification.
Challen GA, Pietras EM, Cabezas Wallscheid N, Signer RA.
Experimental Hematology. In Press. Full Text

Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging.
Kruta M, Sunshine M, Chua BA, Fu Y, Chawla A, Dillingham CH, Hidalgo San Jose L, De Jong B, Zhou FJ, Signer RA.
Cell Stem Cell. In Press. Full Text

Developmental Stage-Specific Changes in Protein Synthesis Differentially Sensitize Hematopoietic Stem Cells and Erythroid Progenitors to Impaired Ribosome Biogenesis.
Magee JA, Signer RA.
Stem Cell Reports. 2021;16(1):20-28. Full Text

ERADicating stem cells from their niche.
Lam K, Signer RA.
Nature Cell Biology. 2020;22(10):1155-1157. Full Text

Hematopoietic Stem Cell Regulation by the Proteostasis Network.
Chua BA, Signer RA.
Current Opinion in Hematology. 2020; 27(4):254-263. Full Text

Post-Transcriptional Regulation of Homeostatic, Stressed, and Malignant Stem Cells.
Chua BA, Van Der Werf I, Jamieson C, Signer RA.
Cell Stem Cell. 2020; 26(2):138-159. Full Text

Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal.
Hidalgo San Jose L, Sunshine M, Dillingham CH, Chua BA, Kruta M, Hong Y, Hatters DM, Signer RA.
Cell Reports. 2020; 30(1):69-80. Full Text

Cell-type-specific quantification of protein synthesis in vivo.
Hidalgo San Jose L & Signer RA.
Nature Protocols. 2019; 14(2):441-460. Full Text

Living Up to the Hype: Protein Synthesis Promotes Hypertranscription in Embryonic Stem Cells.
Kruta M & Signer RA.
Cell Stem Cell. 2018; 22(3):281-282. Full Text

CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo.
Sebastian NT, Zaikos TD, Terry V, Taschuck F, McNamara LA, Onafuwa-Nuga A, Yucha R, Signer RA, Riddell J 4th, Bixby D, Markowitz N, Morrison SJ, Collins KL.
PLoS Pathogens. 2017; 13(7):e1006509. Full Text

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation.
Liu X, Zhang Y, Ni M, Cao H, Signer RA, Li D, Li M, Gu Z, Hu Z, Dickerson KE, Weinberg SE, Chandel NS, DeBerardinis RJ, Zhou F, Shao Z, Xu J.
Nature Cell Biology. 2017; 19(6):626-638. Full Text

Distinct Brca1 mutations differentially reduce hematopoietic stem cell function.
Mgbemena VE*, Signer RA*, Wijayatunge R, Laxson T, Morrison SJ, Ross TS.
Cell Reports. 2017; 18:947-960. Full Text

The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs.
Signer RA*, Qi L, Zhao Z, Thompson D, Sigova AA, Fan ZP, DeMartino GN, Young RA, Sonenberg N, Morrison SJ*.
Genes and Development. 2016; 30:1698-1703. Full Text

Pten cell autonomously modulates the hematopoietic stem cell response to mobilizing cytokines.
Porter SN, Cluster AS, Signer RA, Voigtmann J, Monlish DA, Schuettpelz LG, Magee JA.
Stem Cell Reports. 2016; 6:806-814. Full Text

Suppression of SWI/SNF component Arid1a promotes mammalian regeneration through chromatin remodeling.
Sun X, Chuang J, Kanchwala M, Wu L, Celen C, Li L, Liang H, Zhang S, Maples T, Nguyen LH, Wang SC, Signer RA, Srouri M, Nassour I, Liu X, Xu J, Wu M, Zhao Y, Kuo Y, Wang Z, Xing C, Zhu H.
Cell Stem Cell. 2016; 18:456-466. Full Text

Lens regeneration using endogenous stem cells with gain of visual function.
Lin H, Ouyang H, Zhu J, Huang S, Liu Z, Chen S, Cao G, Li G, Signer RA, Xu Y, Chung C, Zhang Y, Lin D, Patel S, Wu F, Cai H, Hou J, Wen C, Jafari M, Liu X, Luo L, Zhu J, Qiu A, Hou R, Chen B, Chen J, Granet D, Heichel C, Shang F, Li X, Krawczyk M, Skowronska-Krawczyk D, Wang Y, Shi W, Chen D, Zhong Z, Zhong S, Zhang L, Chen S, Morrison SJ, Maas RL, Zhang K, Liu Y.
Nature. 2016; 531:323-328.  Full Text

Cellular differences in protein synthesis regulate tissue homeostasis.
Buszczak M, Signer RA, Morrison SJ.
Cell. 2014; 159:242-251. Full Text

Prospective identification and isolation of functionally distinct populations of neural stem cells and neurosphere-initiating cells in the adult forebrain.
Mich JA*, Signer RA*, Nakada D, Pineda A, Burgess RJ, Vue TY, Johnson JE, Morrison SJ.
eLife. 2014; 10.7554/eLife.02669. Full Text

Haematopoietic stem cells require a highly regulated protein synthesis rate.
Signer RA, Magee JA, Salic A, Morrison SJ.
Nature. 2014; 509:49-54. Full Text

Mechanisms that regulate stem cell aging and life span.
Signer RA & Morrison SJ.
Cell Stem Cell. 2013; 12:152-165. Full Text

Fibroblast Growth Factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a.
Berent-Maoz B, Montecino-Rodriguez E, Signer RA, Dorshkind K.
Blood. 2012; 119:5715-5721. Full Text

Immature B cell progenitors survive oncogenic stress and efficiently initiate Ph+ B-acute lymphoblastic leukemia.
Signer RA*, Montecino-Rodriguez E*, Witte ON, Dorshkind K.
Blood. 2010; 116:2522-2530. Full Text

The ageing immune system: is it ever too old to become young again?
Dorshkind K, Montecino-Rodriguez E, Signer RA.
Nature Reviews Immunology. 2009; 9:57-62. Full Text

Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf.
Signer RA, Montecino-Rodriguez E, Witte O, Dorshkind K.
Genes and Development. 2008; 22:3115-3120. Full Text

Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia.
Signer RA, Montecino-Rodriguez E, Witte ON, McLaughlin J, Dorshkind K.
Blood. 2007; 110:1831-1839. Full Text

Aging, B lymphopoiesis, and patterns of leukemogenesis.
Signer RA, Montecino-Rodriguez E, Dorshkind K.
Experimental Gerontology. 2007; 42:391-395. Full Text

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