Publications

CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo.
Sebastian NT, Zaikos TD, Terry V, Taschuck F, McNamara LA, Onafuwa-Nuga A, Yucha R, Signer RA, Riddell J 4th, Bixby D, Markowitz N, Morrison SJ, Collins KL.
PLoS Pathogens. 2017; 13(7):e1006509. PubMed

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation.
Liu X, Zhang Y, Ni M, Cao H, Signer RA, Li D, Li M, Gu Z, Hu Z, Dickerson KE, Weinberg SE, Chandel NS, DeBerardinis RJ, Zhou F, Shao Z, Xu J.
Nature Cell Biology. 2017; 19(6):626-638. PubMed

Distinct Brca1 mutations differentially reduce hematopoietic stem cell function.
Mgbemena VE*, Signer RA*, Wijayatunge R, Laxson T, Morrison SJ, Ross TS.
Cell Reports. 2017; 18:947-960. PubMed

The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs.
Signer RA*, Qi L, Zhao Z, Thompson D, Sigova AA, Fan ZP, DeMartino GN, Young RA, Sonenberg N, Morrison SJ*.
Genes and Development. 2016; 30:1698-1703. PubMed

Pten cell autonomously modulates the hematopoietic stem cell response to mobilizing cytokines.
Porter SN, Cluster AS, Signer RA, Voigtmann J, Monlish DA, Schuettpelz LG, Magee JA.
Stem Cell Reports. 2016; 6:806-814. PubMed

Suppression of SWI/SNF component Arid1a promotes mammalian regeneration through chromatin remodeling.
Sun X, Chuang J, Kanchwala M, Wu L, Celen C, Li L, Liang H, Zhang S, Maples T, Nguyen LH, Wang SC, Signer RA, Srouri M, Nassour I, Liu X, Xu J, Wu M, Zhao Y, Kuo Y, Wang Z, Xing C, Zhu H.
Cell Stem Cell. 2016; 18:456-466. PubMed

Lens regeneration using endogenous stem cells with gain of visual function.
Lin H, Ouyang H, Zhu J, Huang S, Liu Z, Chen S, Cao G, Li G, Signer RA, Xu Y, Chung C, Zhang Y, Lin D, Patel S, Wu F, Cai H, Hou J, Wen C, Jafari M, Liu X, Luo L, Zhu J, Qiu A, Hou R, Chen B, Chen J, Granet D, Heichel C, Shang F, Li X, Krawczyk M, Skowronska-Krawczyk D, Wang Y, Shi W, Chen D, Zhong Z, Zhong S, Zhang L, Chen S, Morrison SJ, Maas RL, Zhang K, Liu Y.
Nature. 2016; 531:323-328.  PubMed

Cellular differences in protein synthesis regulate tissue homeostasis.
Buszczak M, Signer RA, Morrison SJ.
Cell. 2014; 159:242-251. PubMed

Prospective identification and isolation of functionally distinct populations of neural stem cells and neurosphere-initiating cells in the adult forebrain.
Mich JA*, Signer RA*, Nakada D, Pineda A, Burgess RJ, Vue TY, Johnson JE, Morrison SJ.
eLife. 2014; 10.7554/eLife.02669. PubMed

Haematopoietic stem cells require a highly regulated protein synthesis rate.
Signer RA, Magee JA, Salic A, Morrison SJ.
Nature. 2014; 509:49-54. PubMed

Mechanisms that regulate stem cell aging and life span.
Signer RA & Morrison SJ.
Cell Stem Cell. 2013; 12:152-165. PubMed

Fibroblast Growth Factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a.
Berent-Maoz B, Montecino-Rodriguez E, Signer RA, Dorshkind K.
Blood. 2012; 119:5715-5721. PubMed

Immature B cell progenitors survive oncogenic stress and efficiently initiate Ph+ B-acute lymphoblastic leukemia.
Signer RA*, Montecino-Rodriguez E*, Witte ON, Dorshkind K.
Blood. 2010; 116:2522-2530. PubMed

The ageing immune system: is it ever too old to become young again?
Dorshkind K, Montecino-Rodriguez E, Signer RA.
Nature Reviews Immunology. 2009; 9:57-62. PubMed

Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf.
Signer RA, Montecino-Rodriguez E, Witte O, Dorshkind K.
Genes and Development. 2008; 22:3115-3120. PubMed

Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia.
Signer RA, Montecino-Rodriguez E, Witte ON, McLaughlin J, Dorshkind K.
Blood. 2007; 110:1831-1839. PubMed

Aging, B lymphopoiesis, and patterns of leukemogenesis.
Signer RA, Montecino-Rodriguez E, Dorshkind K.
Experimental Gerontology. 2007; 42:391-395. PubMed

 

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