Medical News Today
BRCA1 gene is key for blood forming stem cells
Researchers have discovered that the BRCA1 gene is required for the survival of blood forming stem cells, which could explain why patients with BRCA1 mutations do not have an elevated risk for leukemia. The stem cells die before they have an opportunity to transform into a blood cancer.
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The Academic Minute
Cellular Protein Production
The ability of our cells to operate properly is determined by the proteins that we produce. Proteins are not only critical building blocks in the production of new cells but also the enzymes that regulate most cellular processes, such as metabolic pathways.
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Cell Stem Cell (Preview)
Tailor Made Protein Synthesis for HSCs
Translation control is a prevalent form of gene expression regulation in developmental and stem cell biology. A recent paper by Signer et al. (2014) measures protein synthesis in the mouse hematopoietic compartment and reveals the importance of diminished protein production for maintaining hematopoietic stem cell function and restraining oncogenic potential.
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Nature Cell Biology (Research Highlights)
Tight control of HSC protein synthesis
Little is known about the regulation of translation in somatic stem cells, although mutations affecting ribosomal functions and translation in humans have been associated with haematopoietic defects, including cancers.
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Science Daily
Stem cell study opens door to undiscovered world of biology
For the first time, researchers have shown that an essential biological process known as protein synthesis can be studied in adult stem cells — something scientists have long struggled to accomplish. The groundbreaking findings from the Children’s Medical Center Research Institute at UT Southwestern (CRI) also demonstrate that the precise amount of protein produced by blood-forming stem cells is crucial to their function.
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Science Daily
Genetics of Aging and Cancer Resistance
Scientists have identified two genes — p16(Ink4a) and Arf — that sensitize lymphoid progenitor cells to the effects of aging, and confer resistance to leukemogenesis.
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